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	Provedor de dados ArchiMer (2) Autor Lebellenger, Lou (2) Delbarre Ladrat, Christine (1) Passerini, Delphine (1) Verrez-bagnis, Veronique (1) Palavra-chave Vibrio diabolicus (2) Biosynthesis (1) Biosynthesis. (1) Biosynthèse (1) Exopolysaccharide (1) GAGmimetics (1) GAGmimétiques (1) Genetic biodiversity (1) HE800 (1) HE800 EPS (1) Polysaccharides (1) Vibrionaceae (1) Mais... Tipo do documento Text (2) Ano 2018 (1) 2017 (1) País France (2) Idioma Francês (1) Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Comparative genomics reveals a widespread distribution of an exopolysaccharide biosynthesis gene cluster among Vibrionaceae ArchiMer Lebellenger, Lou; Verrez-bagnis, Veronique; Passerini, Delphine; Delbarre Ladrat, Christine. Objectives The eps locus in Vibrio diabolicus is involved in the production of the biotechnologically valuable HE800 EPS. In this study, the distribution and diversity of similar eps gene clusters across Vibrionaceae and its variability in relation to phylogenetic relationship were investigated. The aim was to provide a better knowledge of the eps gene cluster importance and to facilitate discovery of new EPS with potent interesting bioactivities. Results Seventy percent of the 103 genome sequences examined display such an eps locus with a high level of synteny. However, genetic divergence was found inside some monophyletic clades or even between some strains of the same species. It includes gene insertions, truncations, and deletions. Comparative analysis... Tipo: Text Palavras-chave: Vibrionaceae; Exopolysaccharide; Genetic biodiversity; Biosynthesis; Vibrio diabolicus; HE800 EPS. Ano: 2018 URL: https://archimer.ifremer.fr/doc/00424/53536/54392.pdf Etude de la biosynthèse des polysaccharides bactériens : vers la production recombinante d'hétéropolysaccharide ArchiMer Lebellenger, Lou. The marine bacteria Vibrio diabolicus produces an exopolysaccharide (EPS) called HE800. The native form of HE800 has already shown biological efficiency in bone healing. It is studied as glycosaminoglycan-mimetic for applications in cosmetic and human health. To enhance biotechnological applications of polysaccharides, the chemical structures should be properly controlled; moreover, the production yield could also be a bottleneck. The genetic cluster of the HE800 EPS biosynthesis has been identified in 2014. However, the biosynthesis molecular mechanisms and regulations remain sometimes unclear. The main objective of this work is to obtain a recombinant production of the HE800 EPS in the common host Escherichia coli, to improve the knowledge of its... Tipo: Text Palavras-chave: Vibrio diabolicus; Polysaccharides; HE800; GAGmimétiques; Biosynthèse; Vibrio diabolicus; Polysaccharides; HE800; GAGmimetics; Biosynthesis.. Ano: 2017 URL: https://archimer.ifremer.fr/doc/00497/60911/64261.pdf Registros recuperados: 2 Primeira ... 1 ... Última

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